Werthein received her Masters of Architecture from the University of Buenos Aires (1993). For inSite_05 Wertheim created what turned out to be a highly controversial project entitled "Brinco" (Jump) that has the artist designing a high top tennis shoe inspired by the border region of Mexico and the U.S. The shoe was designed to assist illegal immigrants cross the border into the United States. The shoe given away to immigrants on the Mexican side and was also sold at a fashionable boutique in San Diego for over $200 USD. The shoe was manufactured cheaply in China in order to underscore the tension between process/manufacturing and design/conceptualization in a region known for the growth and mobility of corporate maquiladoras.

The shoes include a compass, a flashlight for night crossing. The pocket in the tongue hides money or some Tylenol in case of injury. The back ankle features Mexico's patron saint of migrants. A map - printed on the shoe's removable insole - shows the most popular illegal routes from Tijuana into San Diego.

Werthein’s selected solo exhibitions include: Chinati Foundation (Thoughts Come to Mind); Centro Cultural Borjes (Buenos Aires), Bronx Museum of Art (Manicurated); Kent Gallery (Turismo); Museo de Arte Contemporaneo Bahia Blanca, Ruth Benzacar Galeria (Buenos Aires), Centro Cultural San Martin (Buenos Aires). She has been included in exhibitions at El Museo del Barrio, Apex Art, The Center for Curatorial Studies at Bard (curated by Victoria Noorthoorn); 2000 Havana Biennial (Cuba); and the 29ª Bienal de Pontevedra (2006) Imagined Movements between Galicia and the Southern Cone Argentina – Chile - Uruguay.

Curator María Fernanda Cartagena speaks to Werthein in 2005 about her recent work and her "Brinco" project.